Retrospective immunogenicity analysis of seasonal flu H3N2 vaccines recommended in the past ten years using immunized animal sera.

Influenza A (H3N2) virus (A/H3N2) has complex antigenic evolution, resulting in frequent vaccine strain updates. We aimed to evaluate the protective effect of the vaccine strains on the circulating strains from past ten years and provide a basis for finding a broader and more efficient A/H3N2 vaccine strain.

2022-12-22

Increasing diversity in connectomics with the Chinese Human Connectome Project

Cultural differences and biological diversity play important roles in shaping human brain structure and function.

2022-12-20

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Continuous evolution of Omicron has led to a rapid and simultaneous emergence of numerous variants that display growth advantages over BA.5 1. Despite their divergent evolutionary courses, mutations on their receptor-binding domain (RBD) converge on several hotspots.

2022-12-19

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

SARS-CoV-2 Omicron sublineages have escaped most RBD-targeting therapeutic neutralizing antibodies (NAbs), which proves the previous NAb drug screening strategies deficient against the fast-evolving SARS-CoV-2. Better broad NAb drug candidate selection methods are needed.

2022-12-01

A transformation clustering algorithm and its application in polyribosomes structural profiling

Multimodal neuroimaging plays an important role in neuroscience research.Integrated noninvasive neuroimaging modalities, such as magnetoencephalography(MEG),electroencephalography (EEG) and functional near-infrared spectroscopy(fNIRS),allow neural activity and related physiological processes in the

2022-11-11

Structural dynamics of AAA+ ATPase Drg1 and mechanism of benzo-diazaborine inhibition

The type II AAA + ATPase Drg1 is a ribosome assembly factor, functioning to release Rlp24 from the pre-60S particle just exported from nucleus, and its activity in can be inhibited by a drug molecule diazaborine.

2022-11-09

Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota

Durable antibody immunity depends on long-lived plasma cells (LLPCs) that primarily reside in the bone marrow (BM).

2022-10-31

Individualized functional connectome identified generalizable biomarkers for psychiatric symptoms in transdiagnostic patients

Substantial clinical heterogeneity and comorbidity inherent amongst mental disorders limit the identification of neuroimaging biomarkers that can reliably track clinical symptoms.

2022-10-31

The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

Blocking PD-1/PD-L1 signaling transforms cancer therapy and is assumed to unleash exhausted tumor-reactive CD8+ T cells in the tumor microenvironment (TME). However, recent studies have also indicated that the systemic tumor-reactive CD8+ T cells may respond to PD-1/PD-L1 immunotherapy.

2022-10-27

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

Recently emerged SARS-CoV-2 Omicron subvariant,BA.2.75,displayed a local growth advantage over BA.2.38,BA.2.76 and BA.5 in India.The underlying mechanism of BA.2.75's enhanced infectivity, especially compared to BA.5,remains unclear.Herewe show that BA.2.75 exhibits substantially higher ACE2-binding

2022-10-06